Transporter Biology Overview

In providing a transporter biology overview, it is important to note that there are more than 400 currently known unique human transporters. Transporters are transmembrane proteins that act as nature’s gatekeeper for cellular entry and exit by facilitating the movement of substances, drugs and endogenous compounds such as hormones and neurotransmitters, across cell and organ membranes. There is a growing body of evidence that illustrates the importance of transporter study in multiple areas of drug discovery and development; both the FDA and EMA have transporter study requirements for drug-drug interaction (DDI) studies. Transporters can mediate drug disposition and control drug levels because they are expressed deferentially in various tissues and organs.

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Transporter Biology Overview

Liver

Intestine

Kidney

Blood-Brain Barrier