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SNAT1 Transporter Assay (SLC38A2)

Thank you for visiting the SNAT1 Transporter Assay page. We are working diligently to update this page. In the meantime, please contact us for additional information. SNAT1 Transporter Assay Relevance – Amino acid transport Single or Multi-Transporter Model – Single Transporter Type – Uptake Cell Model – MDCK-II Assay Type – Intracellular accumulation Exactly Matched Control Cells – Yes Species – Human Probe Substrate – MeAIB Subcellular Localization in Assay Model – Basolateral(…)

RFC Transporter Assay (SLC19A1)

Thank you for visiting the RFC Transporter Assay page. We are working diligently to update this page with more information. In the meantime, please contact us for additional information. RFC Transporter Assay Relevance – Vitamin transport Single or Multi-Transporter Model – Single Transporter Type – Uptake Cell Model – MDCK-II Assay Type – Intracellular accumulation Exactly Matched Control Cells – Yes Species – Human Probe Substrate – Methotrexate Subcellular Localization in(…)

PCFT Transporter Assay (SLC46A1)

The Proton-Coupled Folate Transporter, PCFT, is a proton-folate symporter that couples the uptake of folates to the flow of protons down an electrochemical gradient. PCFT is a member of the major facilitator superfamily (MFS) of transporters; it functions optimally at acidic pH, and is primarily involved in the intestinal absorption of dietary folates. PCFT is(…)

MRP1 Transporter Assay (ABCC1)

Thank you for visiting the MRP1 Transporter Assay page. We are working diligently to update this page with more information. In the meantime, please contact us for additional information. MRP1 Transporter Assay Relevance – Drug resistance Single or Multi-Transporter Model – Single Transporter Type – Vesicle Model – Vesicle Assay Type – Vesicular accumulation Exactly Matched Control Cells – Yes Species – Human Probe Substrate – Estradiol-17-ß-D-glucuronide Subcellular(…)

TRIUMPH Seminar, Cambridge, MA – September 2014

Transporter Research in Drug Development – An Industry Perspective Thursday, September 25th, 2014 – 9:30 AM– 3:00 PM EST Le Méridien Cambridge-MIT | 20 Sidney Street, Cambridge, MA REGISTER HERE using our contact form or email Rachel Whisnant at rwhisnant@optiviabio.com Talk Titles & Speakers: Dr. Ayman El-Kattan, Associate Research Fellow, Pfizer – Moderator Dr. David Rodrigues, Research Fellow,(…)

Multiple Transporter Models for CNS

Multiple transporter models are critical to the study of brain penetration. Ability to cross the blood-brain barrier (BBB) depends on the relative contributions of uptake and efflux transporters. To illustrate how the model could work Optivia scientists put together a multi-transporter model to study triptans. Triptans are hydrophilic compounds, many of them are substrates of(…)

Quintuple Multi-Transporter Model for Creatinine Clearance OAT2/OCT2/OCT3/MATE1/MATE2K

Opti-Expression technology was used to develop a Quintuple Multi-Transporter Model for Creatinine Clearance OAT2/OCT2/OCT3/MATE1/MATE2K which was used to to investigate the role of multiple transporters in the kidney.  In this example a model was developed for studying the effect of compounds on creatinine clearance. Five major transporters were identified; OAT2, OCT2 and OCT3 on the basolateral side(…)

MRP4 Transporter Assay (ABCC4)

Thank you for visiting the MRP4 Transporter Assay page. We are working diligently to update this page with more information. In the meantime, please contact us for additional information. MRP4 Transporter Assay Relevance – Renal tubular secretion; hepatic efflux; drug resistance Single or Multi-Transporter Model – Single Transporter Type – Vesicle Model – Vesicle Assay Type – Vesicular accumulation Exactly Matched Control Cells – Yes(…)