Key Optivia Publications


Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110
Zhang Y, Warren MS, Zhang X, Diamond S, Williams B, Punwani N, Huang J, Huang Y, Yeleswaram S. Drug Metab Dispos. 2015 Apr;43(4):485-9. doi: 10.1124/dmd.114.060673. Epub 2015 Jan 20.

Contribution of the Organic Anion Transporter OAT2 to the Renal Active Tubular Secretion of Creatinine and Mechanism for Serum Creatinine Elevations Caused by Cobicistat. Eve-Irene Lepist, Xuexiang Zhang, Jia Hao, Jane Huang, Alan Kosaka, Gabriel Birkus, Bernard P. Murray, Roy Bannister, Tomas Cihlar, Yong Huang and Adrian S. Ray. Kidney International advance online publication, 19 March 2014; doi:10.1038/ki.2014.66

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational ModelingWittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. J Med Chem. 2013 Feb 14;56(3):781-95. doi: 10.1021/jm301302s. Epub 2013 Jan 22.

Interactions of Bilastine, A New Oral H₁ Antihistamine, with Human Transporter SystemsLucero ML, Gonzalo A, Ganza A, Leal N, Soengas I, Ioja E, Gedey S, Jahic M, Bednarczyk D. Drug Chem Toxicol. 2012 Oct;35(4):472.

Fluorescence-Based Assays for the Assessment of Drug Interaction with the Human Transporters OATP1B1 and OATP1B3. Bednarczyk D. Anal Biochem. 2010 October 1;405(1): 50–58.

A Robust, Consistent and Scalable Functional Transporter Assay Method Based on Transient Expression of Specific Transporters in Polarized Cell Monolayers. Bednarczyk D, M. Jahic, J. Wang, Huang Y. Drug Metab Rev.  40(Suppl 3):271, 2008


Key Optivia Publications

Posters Are Available Upon Request - Contact Us.

Transporter-Induced Protein Binding Shift (TIPBS) Hypothesis and Modeling. Jason Baik and Yong Huang. Poster# P272. ISSX North America, Orlando, FL, 2015.

An Integrated Approach to More Accurately Assess Cholestatic Liability of Drugs. Cheul Cho, Eric Pludwinski, Eric Novik, Yong Huang, and Mark S. Warren. Poster# P245. ISSX North America, Orlando, FL, 2015.

Should Total Plasma Drug Concentration Be Used to Predict Transporter Mediated Drug-Drug Interactions for Highly Protein Bound Drugs? Mirza Jahic, Jason Baik, Chien-Ming Li, Wenjie Jiang, Xuexiang Zhang, Mark S. Warren and Yong Huang. P164. European ISSX 2015, Glasgow, Scotland.

Anti-HIV Protease Inhibitors May Aggravate Rifampicin Induced Liver Injury Through Multifaceted Interactions On Hepatic Transporters. Mark S. Warren, Chien-Ming Li, Jason Baik, and Yong Huang. PI-029. ASCPT 2015, New Orleans, LA.

In vitro-In vivo Correlation (IVIVC) of Drug Induced Inhibition of Creatinine Tubular Secretion using MDCK Cells Expressing OCT2/OAT2/OCT3/MATE1/MATE2K Transporters. Xuexiang Zhang, Wenjie Jiang, Chienming Li, Jane Huang, Yong Huang. Abstract ID: 762. ASCPT 2015, New Orleans, LA.

False Negatives May Occur in BCRP Substrate Assessments Depending on the In Vitro Assay System Used. Jason Baik, Wenjie Jiang, Ilene Kaufman, Chien-Ming Li, and Mark S. Warren. W5090. AAPS 2014, San Diego, CA.

Distinct Substrate Transport and Inhibition Properties of MATE1/SLC47A1 Transporter Operating In Efflux versus Uptake Mode. Xuexiang Zhang, Jane Huang and Yong Huang. P437. ISSX 2014, San Francisco, CA.

The Correlations between Transporter Protein Expression, Apparent Transcellular Permeability and Intrinsic Efflux Permeability: A Case Study on BCRP/ABCG2 Transporter. Chien-Ming Li, Jason Baik, Wenjie Jiang, Mark S. Warren and Yong Huang. P447. ISSX 2014, San Francisco, CA.

Measuring Intrinsic Kinetic Constants for P-Glycoprotien Mediated Quinidine Efflux Transport using Intracellular Unbound Concentration in MDR1-MDR1-MDCKII Cells. Jason Baik, Mirza Jahic and Yong Huang. P449. ISSX 2014, San Francisco, CA.

A Novel High-throughput Method for Measuring Intracellular Unbound Fraction. Wenjie Jiang, Mirza Jahic, Jason Baik and Yong Huang.  P448. ISSX 2014, San Francisco, CA.

For posters prior to 2014, please contact us