OCTN1 Transporter Assay (SLC22A4)

The OCTN1 transporter is a cation/zwitterion sodium dependent high affinity carnitine transporter. It is localized widely in many organs including the kidneys, pancreas, prostate, skeletal muscle and heart.

Optivia offers OCTN1 substrate and inhibition assays for transport in polarized mammalian cells. We offer a wide range of studies including single concentration screens up to full kinetic studies to determine the IC50 for OCTN1 inhibitors as well as Vmax and Km values for OCTN2 substrates.

OCTN1 Transporter Assay

Relevance – Renal tubular reabsorption Single or Multi-Transporter Model – Single
Transporter Type – Uptake Cell Model – MDCK-II
Assay Type – Intracellular accumulation Exactly Matched Control Cells – Yes
Species – Human Probe Substrate – Ergothioneine
Subcellular Localization in Assay Model – Apical Inhibition Positive Control – Verapamil