OCTN1 Transporter Assay (SLC22A4)
The OCTN1 transporter is a cation/zwitterion sodium dependent high affinity carnitine transporter. It is localized widely in many organs including the kidneys, pancreas, prostate, skeletal muscle and heart.
Optivia offers OCTN1 substrate and inhibition assays for transport in polarized mammalian cells. We offer a wide range of studies including single concentration screens up to full kinetic studies to determine the IC50 for OCTN1 inhibitors as well as Vmax and Km values for OCTN2 substrates.
OCTN1 Transporter Assay
|Relevance – Renal tubular reabsorption||Single or Multi-Transporter Model – Single|
|Transporter Type – Uptake||Cell Model – MDCK-II|
|Assay Type – Intracellular accumulation||Exactly Matched Control Cells – Yes|
|Species – Human||Probe Substrate – Ergothioneine|
|Subcellular Localization in Assay Model – Apical||Inhibition Positive Control – Verapamil|