Central Nervous System – Opti-CNS™

Central Nervous System – Opti-CNS™ Enriching Piplines and Understanding Risk

There are two categories of transporters in the central nervous system: those situated at the blood-brain barrier controlling uptake and efflux of solutes between blood and brain extracellular fluid; and those found in various regions of the brain and spinal cord regulating CNS function and neurotransmission.

Studying CNS transporters enables pharmaceutical scientists to identify and characterize innovative targets for the treatment of neurological diseases.  This creates a deeper understanding of mechanisms involved in neurotransmission, redox signaling and oxidative stress, and energy metabolism.

Optivia’s scientific team is composed of thought leaders in CNS transporter research and development. We have been awarded grants by both FDA and NIH for correlating therapeutic and adverse effects of drugs and their interactions with a comprehensive panel of CNS transporters. This work allows for a better understanding of the impact on the brain’s physiology and pathology. For a list of available transporters click Opti-CNS panel. For a complete list of fully characterized transporters known to impact the central nervous system, please reference the table below.

TransporterGene NamePredominant CNS endogenous substratesDocumented links to CNS diseases
EAAT1SLC1A3L-Glu, L-AspSchizophrenia, episodic ataxia
EAAT2SLC1A2L-Glu, L-AspNeurodegenerative diseases
EAAT3SLC1A1L-Glu, L-AspObsessive compulsive disorder
ChTSLC5A7CholineAlzheimer's, Parkinson's, dementia
NETSLC6A2Norepinephrine, dopamineADHD, depression
DAT1SLC6A3DopamineMajor depressive disorder, ADHD, substance abuse
SERTSLC6A4SerotoninMajor depressive disorder, anxiety, panic disorder
GlyT1SLC6A9Glycineschizophrenia
GlyT2SLC6A5GlycineHyperekplexia, pain
GAT1SLC6A1GABA, β-alanineEpilepsy, schizophrenia, ADHD
GAT2SLC6A13GABA, β-alanineEpilepsy
GAT3SLC6A11GABA, β-alanineEpilepsy
CT1SLC6A8CreatineCreatine deficiency, mental retardation
BGT1SLC6A12GABA/betaineEpilepsy
PROTSLC6A7ProParkinson's, dystonia
SBAT1SLC6A15Pro, Leu, Gly, AlaDepression
asc1SLC7A10D-Ser, small neutral amino acidsLearning and memory impairment
CAT3SLC7A3Cationic L-amino acidsAllan-Herndon-Dudley syndrome
xCTSLC7A11Cys (anionic form), L-GluOxidative stress, Parkinson's
DMTSLC11A2Cationic metals: Fe2+, Cd2+ etc.Parkinson's, Iron overload, Amyotrophic lateral sclerosis
OCT2SLC22A2Biogenic aminesMajor depressive disorder, schizophrenia, bipolar disorder
OCT3SLC22A3Biogenic aminesMajor depressive disorder, schizophrenia, bipolar disorder
AGC1SLC25A12Aspartate, glutamateAutism, schizophrenia
ENT1SLC29A1AdenosineObsessive compulsive disorder, ischemia
ENT2SLC29A2AdenosineCerebral ischemia
ENT4SLC29A4Adenosine, biogenic aminesMajor depressive disorder, schizophrenia, bipolar Disorder
SNAT1SLC38A1Gln, Ala, Ser, Cys, His, AsnSuicidal behavior
SNAT2SLC38A2Gln, Ala, Ser, Cys, His, AsnSchizophrenia
CTL1SLC44A1CholineNeuroblastoma