Bruno Stieger, Ph.D., Scientific Advisor
Bruno Stieger, PhD is head of the research laboratory of the Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland. He was trained as a biochemist at the Federal Institute of Technology in Zurich Switzerland and holds a PhD in biochemistry from the same institution. The Department of Clinical Pharmacology and Toxicology of the University Hospital Zurich has cloned the major bile salt and drug transport systems of hepatocytes and has identified the founding members of the SLC10A1 and of the SLCO gene families including the sodium-dependent uptake system NTCP (Slc10a1), several organic anion transporting polypeptides OATPs (SLCO), which are important drug transporters (members of the SLCO transporter family) and the bile salt export pump BSEP (ABCB11). The current research interests of the Department are related to i) understand the role of the interaction of drugs with transport systems in the development of acquired liver disease, ii) the investigation of molecular mechanisms of canalicular bile formation with a focus on biliary lipids and iii) regulation of the expression of drug and bile salts transporters.